Phineas Gage y el enigma del córtex prefrontal

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[Phineas Gage and the enigma of the prefrontal cortex].

Perhaps the most famous brain injury in history was a penetrating wound suffered by a rail road worker named Phineas Gage on September 13, 1848. Twelve years after his injury, on the 21st of May, 1860 Phineas Gage died of an epileptic seizure. In 1868 Dr. Harlow gave an outline of Gage's case history and first disclosed his remarkable personality change. One might think this report would assure...

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SOCial NEurOSCiENCE: ThE fOOTPriNTS Of PhiNEaS gagE

757 This paper is based on a keynote address presented at a conference on Neural Systems of Social Behavior held at the University of Texas, Austin, in May 2007. I thank Jennifer Beer for the invitation to present the keynote, the members of the Institute for Personality and Social Research for comments beforehand, Jeff Sherman for the opportunity to prepare the talk for publication, and John C...

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The tale of Phineas Gage, digitally remastered.

The injury of Phineas Gage has fueled research on and fascination with the localization of cerebral functions in the past century and a half. Most physicians and anatomists believed that Gage sustained a largely bilateral injury to the frontal lobes. However, previous studies seem to have overlooked a few less obvious, but essential details. This has led us to reanalyze the injury using three-d...

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Mapping Connectivity Damage in the Case of Phineas Gage

White matter (WM) mapping of the human brain using neuroimaging techniques has gained considerable interest in the neuroscience community. Using diffusion weighted (DWI) and magnetic resonance imaging (MRI), WM fiber pathways between brain regions may be systematically assessed to make inferences concerning their role in normal brain function, influence on behavior, as well as concerning the co...

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Identifying individual differences: An algorithm with application to Phineas Gage

In many research contexts it is useful to group experimental subjects into behavioral “types.” Usually, this is done by pre-specifying a set of candidate decision-making heuristics and assigning each subject to a heuristic in that set. Such approaches might perform poorly when applied to subjects with prefrontal cortex damage, because it can be hard to know what cognitive heuristics such subjec...

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ژورنال

عنوان ژورنال: Neurología

سال: 2012

ISSN: 0213-4853

DOI: 10.1016/j.nrl.2010.07.015